Title:
【発明の名称】アシル化合物
Document Type and Number:
Japanese Patent JP2749458
Kind Code:
B2
Abstract:
Aromatic amide derivatives of formula (I) and their salts are new. (Where R1 = aliphatic hydrocarbon optionally substituted with halogen or OH, or a cycloaliphatic or araliphatic hydrocarbon. X1 = CO, SO2, or OCO with the carbon linked to the N. X2 = aliphatic hydrocarbon (optionally substituted with OH, carboxy, NH2, guanidino, cycloaliphatic or aromatic hydrocarbon) or cycloaliphatic hydrocarbon, with a carbon of the aliphatic optionally bridged by a divalent aliphatic hydrocarbon. R2 = carboxy or its ester or amide derivative, NH2, substituted amino, formyl, acetal derivative of formyl, 1H-tetrazol-5-yl, pyridyl, OH, ether, SR, SOR, SO2R, alkanoyl, sulphamoyl, N-substituted sulphamoyl, PO2H2 or PO3H2. R = H or aliphatic hydrocarbon. X3 = hydrocarbon. R3 = carboxy, 5-tetrazolyl, SO3H, PO2H2, PO3H2 or haloalkylsulphamoyl. Rings A and B are each optionally substd. 121 compounds are specifically claimed, including (S)-N-(1-carboxy -2-methyl)-prop-1-yl) -N-pentanoyl-N- (2'-(1H-tetrazol-5-yl) biphenyl-4-ylmethyl) amine.
Inventors:
Peter Bühlmayer
Franz Ostermaya
Tibur Schmidrin
Franz Ostermaya
Tibur Schmidrin
Application Number:
JP10809791A
Publication Date:
May 13, 1998
Filing Date:
February 19, 1991
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
International Classes:
A61K31/195; A61K31/41; A61K31/44; A61K31/47; A61K31/535; A61K31/675; A61P9/12; C07C229/38; C07C231/00; C07C233/47; C07C233/51; C07C233/54; C07C235/04; C07C271/10; C07C311/48; C07D233/54; C07D233/58; C07D233/64; C07D257/04; C07D401/12; C07D401/14; C07D403/00; C07D405/00; C07D409/00; C07F9/6524; (IPC1-7): C07C233/47; A61K31/195; A61K31/41; C07C235/04; C07C271/10; C07C311/48; C07D257/04
Domestic Patent References:
| JP6323868A |
Attorney, Agent or Firm:
Aoki Akira (3 outside)