Title:
【発明の名称】ムスカリン受容体のアロステリック部位
Document Type and Number:
Japanese Patent JP2003512607
Kind Code:
A
Abstract:
An allosteric site on muscarinic receptors is disclosed, together with its use for screening for compounds capable of modulating the binding of a primary ligand such as acetylcholine to the receptor. The site is characterised herein a series of indolocarbazoles represented by formula (1) and a series of related compounds represented by formula (2). These compounds are capable of binding to the allosteric site to modulate the binding of a primary ligand to the receptors, showing positive, negative and neutral cooperativity and selectivity for muscarinic receptor subtypes.
Inventors:
Bird Sale, Niger
Lazareno, Sebastian
Lazareno, Sebastian
Application Number:
JP2001531835A
Publication Date:
April 02, 2003
Filing Date:
October 20, 2000
Export Citation:
Assignee:
Medical Research Council Technology
International Classes:
G01N33/50; A61K31/437; A61K31/519; A61K31/553; A61K31/569; A61K31/58; A61K45/00; A61P1/04; A61P1/06; A61P1/16; A61P3/10; A61P9/00; A61P11/00; A61P11/06; A61P13/10; A61P17/00; A61P25/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P43/00; C07D471/04; C07D487/04; C07D498/22; C07J7/00; C07J71/00; G01N33/15; G01N33/566; G01N33/94; (IPC1-7): G01N33/50; A61K31/437; A61K31/519; A61K31/553; A61K31/569; A61K31/58; A61K45/00; A61P1/04; A61P1/06; A61P1/16; A61P3/10; A61P9/00; A61P11/00; A61P11/06; A61P13/10; A61P17/00; A61P25/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P43/00; G01N33/15; G01N33/566
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)