Title:
【発明の名称】アミノ酸類似CCK拮抗剤
Document Type and Number:
Japanese Patent JPH04506660
Kind Code:
A
Abstract:
A CCK antagonist compound of formula (I) wherein G is (1) NH2 or (2) substituted amino; R9 is (1) hydrogen, (2) loweralkyl, (3) carboxy-substituted alkyl or (4) carboxyester-substituted alkyl; R10 is (1) hydrogen, (2) loweralkyl, (3) functionalized alkyl or (4) cycloalkyl; D is (1) hydrogen, (2) loweralkyl, (3) functionalized alkyl, (4) cycloalkyl, (5) aryl, (6) functionalized oxyalkyl or (7) heterocyclic; with the proviso that D is other than indolylmethyl, indolinylmethyl or oxindolylmethyl; or R10 taken together with D or R9 taken together with D forms a cyclic group; Z is (1) -C(O)-, (2) -C(S)- or (3) -S(O)2-; B is (1) absent, (2) alkylene, (3) alkenylene, (4) substituted alkenylene, (5) -R26-R27- wherein R26 is absent or -CH2- and R27 is -O-, -S-, -NH- or -N(loweralkyl)- or (6) -R27-CH2- wherein R27 is defined as above; and Ar is (1) aryl or (2) a heterocyclic group.
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Inventors:
Carwin, The Ames F, Giunia
Application Number:
JP50964390A
Publication Date:
November 19, 1992
Filing Date:
June 26, 1990
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
A61K31/16; A61K31/195; A61K31/27; A61K31/38; A61K31/381; A61K31/47; A61P1/00; A61P3/04; A61P3/08; A61P25/00; A61P25/04; C07C237/06; C07C237/20; C07C237/22; C07C255/24; C07C255/29; C07C255/41; C07C271/22; C07C271/24; C07C275/42; C07C275/62; C07C311/13; C07C311/19; C07C317/14; C07C323/58; C07C327/38; C07C335/04; C07D207/16; C07D209/20; C07D209/42; C07D213/56; C07D213/75; C07D213/82; C07D215/48; C07D215/54; C07D215/56; C07D233/54; C07D295/185; C07D307/84; C07D333/20; C07D333/24; C07D333/70; C07D401/12; C07D403/06; C07D403/12; C07D405/12; C07D409/12; C07D471/04; C07K5/02; C07K5/078; A61K38/00; (IPC1-7): C07C237/06
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)