Title:
【発明の名称】抗生物質レウテリン
Document Type and Number:
Japanese Patent JP3007092
Kind Code:
B2
Abstract:
Antibiotic is produced by placing cells of Lactobacillus reuteri (LR) under conditions suitable for prodn. Pref. process is carried at in the presence of glycerol, and with a reduced oxygen tension. Also claimed is an antibiotic and its derivs., effective in inhibiting Gram-positive and Gram-negative bacteria and the eucaryotic organisms S. cerevisiae and Trypanosoma cruzi, contg., in wt.%, carbon, 48.65%; hydrogen, 8.11%; oxygen, 43.24%; having a mol. wt. of 148g per mole; being soluble in water; nonresistant to heat at pH9 and resistant to proteases and nucleases; and exhibiting characteristic elution with water of 0.01 M H2SO4 between 1,3-propanediol and glycerol on HPLC. The LR produces an antibiotic called reuterin. Reuterin is a broad-spectrum antimicrobial agent. J6 is also effective in preventing virus replication. LR may be added to animal food to optimise the conditions for reuterin prodn. in the gastrointestinal tract. Teuterin inhibits ribonucleotide reductase involved in DNA synthesis and can be used to inhibit the growth of bacteria, yeasts moulds, protoxoa, viruses and neoplastic and normal animal cells Reuterin is also an effective food preservative.
Inventors:
Dob Rogoth, Walter Jay
Lindgren, Sven Yi
Lindgren, Sven Yi
Application Number:
JP50416888A
Publication Date:
February 07, 2000
Filing Date:
April 28, 1988
Export Citation:
Assignee:
Biogaia biologics abby
International Classes:
A23K1/16; A01N43/32; A01N63/02; A23K20/195; A23L3/3544; A23L3/3571; A61K31/335; A61K31/357; A61P31/04; C07D319/06; C07D321/12; C12N1/00; C12N1/20; C12P17/06; C12P17/08; C12Q1/04; C12Q1/18; C12R1/225; C12P; (IPC1-7): C12P17/02; A23L3/3481; A23L3/3544; A61P31/04; A61K31/335; A61K31/357; C07D313/18; C07D319/06; C12N1/20; C12P7/24; C12P17/06
Attorney, Agent or Firm:
Heikichi Odashima