Title:
【発明の名称】抗増殖性キナゾリン
Document Type and Number:
Japanese Patent JP3272357
Kind Code:
B2
Abstract:
Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.
Inventors:
Webber, Stephen Yee
Breckman, Ted M
John Attard
Jones, Terrance Earl
Vernie, Michael Dee
Breckman, Ted M
John Attard
Jones, Terrance Earl
Vernie, Michael Dee
Application Number:
JP51751493A
Publication Date:
April 08, 2002
Filing Date:
March 26, 1993
Export Citation:
Assignee:
Agron Pharmaceuticals Incorporated
International Classes:
A61K31/505; A61K31/517; A61P31/04; A61P31/10; A61P35/00; C07D239/88; C07D239/90; C07D239/91; C07D239/93; C07D239/95; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D417/12; (IPC1-7): C07D239/90; A61K31/517; A61P31/04; A61P31/10; A61P35/00; C07D239/91; C07D239/93
Other References:
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，（１９７３），１６（１１），ｐ１２３３−１２３
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)