Title:
【発明の名称】抗腫瘍溶液
Document Type and Number:
Japanese Patent JP3101702
Kind Code:
B2
Abstract:
Disclosed are antineoplastic solutions for direct intratumoral delivery. The solutions are formulated using antineoplastic agents dissolved in organic, water miscible, solvent vehicles. The vehicle is selected such that a) the agent is dissolved in the vehicle, b) the agent is stable and bioavailable in the vehicle, and c) the vehicle readily diffuses through and permeates tumorous tissue. The solution is injected directly into the tumor and, as the vehicle permeates the tumor tissue it transports the agent therewith. In this way therapeutically effective levels of antinoeplastic agent are effectively and rapidly delivered and disseminated into the tumor mass with little or no dissemination into surrounding healthy tissue.
Inventors:
Petronigro, Dennis Di
Application Number:
JP50766290A
Publication Date:
October 23, 2000
Filing Date:
May 08, 1990
Export Citation:
Assignee:
Petronigro, Dennis Di
International Classes:
A61K9/00; A61K31/00; A61K31/04; A61K31/13; A61K31/17; A61K31/28; A61K45/00; A61K47/10; A61K9/08; A61P35/00; (IPC1-7): A61K9/08; A61K31/04; A61K31/13; A61K31/17; A61K31/28; A61K45/00; A61K47/10; A61P35/00
Domestic Patent References:
| JP6245593A | ||||
| JP6323888A |
Other References:
Ｊ．Ｎｅｕｒｏｓｕｒｇ．，Ｖｏｌ．６５，ｐ．６７１−６７８，１９８６
Attorney, Agent or Firm:
Masaki Yamakawa (4 outside)