Title:
【発明の名称】人工腸管
Document Type and Number:
Japanese Patent JP2001525705
Kind Code:
A
Abstract:
An artificial gut (100) comprises a first hollow fiber (203) having an inner surface (215) that is lined with at least a portion of a layer of one or more of a plurality of biological components (205) that typically line a mammalian gut. Further, a second hollow fiber (201) is adjacent the first hollow fiber. The layer of one or more of the plurality of biological components can consist essentially of enterocytes. The enterocyte-lined inner surface is perfused with a feeding solution containing nutrients, and the enterocytes absorb, process, and transport the nutrients across the wall of the first hollow fiber. The nutrients eventually diffuse into the second hollow fiber. A perfusate selected from the group consisting of culture medium, blood, and plasma, can perfuse an inner surface of the second hollow fiber, whereby the perfusate is nourished by the nutrients.
Inventors:
Rozuga, Jasek
Demetriu, Achilles, A
Demetriu, Achilles, A
Application Number:
JP54966598A
Publication Date:
December 11, 2001
Filing Date:
May 13, 1998
Export Citation:
Assignee:
Cedar Sinai Medical Center
International Classes:
A61L27/00; A61F2/00; A61F2/02; A61F2/04; A61L27/38; A61M1/18; G09B23/28; A61M1/16; A61M1/34; (IPC1-7): A61F2/04; A61F2/00; A61L27/00
Attorney, Agent or Firm:
Akira Asamura (3 outside)