Title:
【発明の名称】弱毒ウイルスとその製造方法
Document Type and Number:
Japanese Patent JPH10507077
Kind Code:
A
Abstract:
Disclosed are attenuated viruses, not naturally occurring, that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably, the methylation sites are added into the genome of the virus by introducing an additional CG segment into the genome by means of a silent mutation. The attenuated viruses are useful for producing an immune response, including both the production of antibodies in animals for diagnostic use and the induction of protective immunity in a subject. Pharmaceutical formulations and methods of making the attenuated viruses are also disclosed.
Inventors:
Nice, Jonathan W
Application Number:
JP51271996A
Publication Date:
July 14, 1998
Filing Date:
October 05, 1995
Export Citation:
Assignee:
East Carolina University
International Classes:
C12N15/09; A61K31/12; A61K31/21; A61P37/00; C12N7/00; C12N7/04; C12N15/867; C12Q1/70; C12R1/92; (IPC1-7): C12N15/09; A61K31/12; A61K31/21; C12N7/00; C12N7/04
Attorney, Agent or Firm:
Nao Okuyama (3 others)