Title:
【発明の名称】アザ環式化合物、それらの製造方法、及びそれらを含む医薬組成物
Document Type and Number:
Japanese Patent JPH06510034
Kind Code:
A
Abstract:
Compounds of formula (I), and salts and prodrugs thereof wherein n is 1, 2 or 3; X represents O or S; R<1> represents optionally substituted phenyl; R<2> represents aryl, heteroaryl, benzhydryl, or benzyl; R<4> and R<5> each independently represent H, halo, CH2OR<9>, C1-6alkyl, oxo, CO2R<1><0> or CONR<1><0>R<1><1>; R<8> represents H, COR<9>, CO2R<1><0> or optionally substituted C1-6alkyl; R<9> represents H, C1-6alkyl or phenyl; and R<1><0> and R<1><1> each independently represent H or C1-6alkyl; are tachykinin antagonists. They and compositions thereof are useful in medicine.
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Inventors:
Baker, Raymond
Harrison, Tamothy
Swain, Christopher Jiyoung
Williams, Brian Jiyoung
Harrison, Tamothy
Swain, Christopher Jiyoung
Williams, Brian Jiyoung
Application Number:
JP50417993A
Publication Date:
November 10, 1994
Filing Date:
August 13, 1992
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
A61K31/395; A61K31/397; A61K31/40; A61K31/4433; A61K31/445; A61K31/451; A61P25/00; A61P25/02; A61P29/00; A61P43/00; C07D205/04; C07D205/08; C07D207/12; C07D211/42; C07D211/54; C07D211/74; C07D211/76; C07D401/04; C07D409/04; (IPC1-7): C07D207/12; A61K31/395; A61K31/40; A61K31/445; C07D205/08; C07D211/42; C07D211/54; C07D409/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)