Title:
【発明の名称】アルツハイマー病の死前診断ならびにアミロイド沈着のイン・ビボのイメージ化及び予防のためのアゾ化合物
Document Type and Number:
Japanese Patent JPH11505526
Kind Code:
A
Abstract:
Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
Inventors:
Crank, William Yee
Pete Griew, Jay W
Matisse, Chester A, Junior
Pete Griew, Jay W
Matisse, Chester A, Junior
Application Number:
JP53338396A
Publication Date:
May 21, 1999
Filing Date:
May 01, 1996
Export Citation:
Assignee:
University of Pittsburgh
International Classes:
A61K49/00; C07C59/64; C07C63/66; C07C245/08; C07C245/10; C07C309/46; C07C309/47; C07D209/48; C07D213/02; C07D213/80; C07D217/24; C07D221/14; C07D237/28; C07D237/32; C07D257/04; C07D261/20; G01N33/68; C07D265/02; C07D265/26; C07D271/10; C07D295/22; C07D403/06; C07D413/06; C07F7/22; C09B35/14; (IPC1-7): C07C245/08; A61K49/00; C07C63/66; C07C245/10; C07C309/46; C07C309/47; C07D213/02; C07D237/32; C07D257/04; C07D261/20; C07D295/22; C07D403/06; C07D413/06; C07F7/22; C09B35/14; G01N33/68
Attorney, Agent or Firm:
Nao Okuyama (3 others)