Title:
【発明の名称】カルシウム拮抗剤
Document Type and Number:
Japanese Patent JP2879918
Kind Code:
B2
Abstract:
The present invention is directed to a new class of cyclic guanidines of the formula: in which Q is represented by a substituent selected from the group consisting of (CH2)n in which n is an integer from 2-10, A is a substituent selected from the group consisting of -NH-(CH2)m in which m is an integer from 0-5, a piperidino substituent, or a piperazino substituent; both Ar and Ar1 are each independently represented by a phenyl ring, each of which may be optionally substituted with up to 3 substituents, each selected from the group consisting of halogen, alkyl, alkoxy, hydroxy, and trifluoromethyl; and R is represented by either hydrogen or an alkyl; R1 is represented by hydrogen or an alkyl; the tautomers, and optical isomers thereof; and the pharmaceutically acceptable acid addition salts thereof; with the provisos that: 1) when Q is represented by (CH2)2,3,or 4 , then A is not represented by NH-(CH2)o; and 2) when Q is represented by (CH2)2 and R is an alkyl; then A is not NH-(CH2), and to their use as calcium antagonists.
Inventors:
ARUBAATO ANSONII KAA
JON MAIKERU KEIN
SHEN CHAN CHEN
JON MAIKERU KEIN
SHEN CHAN CHEN
Application Number:
JP3129290A
Publication Date:
April 05, 1999
Filing Date:
February 09, 1990
Export Citation:
Assignee:
MERERU PHARM INC
International Classes:
A61K31/395; A61K31/415; A61K31/505; A61K31/55; A61P3/00; A61P3/14; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P19/06; A61P25/08; A61P25/24; A61P25/26; C07D233/48; C07D233/50; C07D235/30; C07D239/14; C07D239/84; C07D243/04; C07D245/02; C07D245/06; C07D401/04; A61K; C07D; (IPC1-7): C07D233/50; A61K31/395; A61K31/415; A61K31/505; A61K31/55; C07D239/14; C07D243/04; C07D245/06; C07D401/04
Other References:
Ｃｈｅｍ．Ｐｈａｒｍ．Ｂｕｌｌ．，２７（７），１５９６−１６０３（１９７９）
Attorney, Agent or Firm:
Katsuro Sasai