Title:
【発明の名称】化学的化合物
Document Type and Number:
Japanese Patent JPH02503752
Kind Code:
A
Abstract:
The invention provides compounds for use in the diagnosis and/or therapy of tumors and/or as an immunosuppressant agent selected from the group consisting of antibodies which bind to IL-4 receptors and IL-4 receptor-binding fragments thereof. A preferred such compound is monoclonal antibody MR6 produced by the hybridoma deposited at the European Collection of Animal Cell Cultures with the accession number 88033002. The invention also extends to the use of the compounds for in vitro removal of graft-versus-host reactive T-lymphocytes prior to bone marrow transplantation and to a novel protein of molecular weight 200,000 daltons functioning as a receptor for IL-4.
Inventors:
Ritzer, Mary Alice
Ratchet mark
Ratchet mark
Application Number:
JP50453189A
Publication Date:
November 08, 1990
Filing Date:
April 06, 1989
Export Citation:
Assignee:
Three-I Research Exploitation Limited
International Classes:
G01N33/53; A61K39/395; A61K51/00; A61K51/10; A61P37/06; C07K14/00; C07K14/005; C07K14/195; C07K14/52; C07K14/54; C07K14/705; C07K16/00; C07K16/28; C12N5/10; C12N15/02; C12P21/00; C12P21/08; G01N33/577; A61K38/00; C12R1/91; (IPC1-7): A61K39/395; A61K43/00; A61K49/02; C07K15/04; C07K15/14; C12N5/20; C12N15/06; C12P21/00; C12P21/08; G01N33/53; G01N33/577
Domestic Patent References:
| JPS63502593A | 1988-09-29 |
Attorney, Agent or Firm:
Chika Takagi (2 outside)