Title:
【発明の名称】キメラアミノ酸類似体
Document Type and Number:
Japanese Patent JPH05500515
Kind Code:
A
Abstract:
A chimeric amino acid analogue is provided suitable for incorporating into peptides which compound is represented by Formula 1: 1 where P1 is preferably an amine protecting agent, and P2 and P3 are preferably amine or guanidine protecting agents. X can be OH, halide, or preferably an activating group suitable for conjugating the compound of Formula 1 to a peptide by conventional means, and m and n are 0-1 and 0-2 respectively. Peptides containing the chimeric amino acid analog are provided and include a platelet-aggregation inhibitor represented by Aaa1-CPdl-Gly-Asp-Aaa2 where Aaa1 is Gly or H, Cpdl is the compound of Formula 1 which has been deprotected and Aaa2 is a hydrophobic amino acid preferably Val.
Inventors:
Webb, Thomas Earl
Application Number:
JP51381190A
Publication Date:
February 04, 1993
Filing Date:
September 24, 1990
Export Citation:
Assignee:
Genentech, Inc.
International Classes:
A61K38/00; A61P7/02; C07D207/16; C07K5/117; C07K7/06; (IPC1-7): A61K37/02; C07D207/16
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)