【発明の名称】クロマン誘導体及びその医薬用途

Title:

【発明の名称】クロマン誘導体及びその医薬用途

Document Type and Number:

Japanese Patent JP2649610

Kind Code:

B2

Abstract:

A chroman derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, and a medicinal use thereof, wherein R<1> is cyano, nitro, trihalomethyl, trihalomethoxy or halogen; R<2> is lower alkoxyalkyl, aryloxyalkyl or dialkoxyalkyl; R<3> is lower alkoxyalkyl or aryloxyalkyl; R<4> is hydroxy, formyloxy or lower alkanoyloxy; X is N-H which may be substituted by lower alkyl, oxygen, sulfur or a single bond; Y is a residue of an aromatic or heterocyclic ring which may be substituted. The compound and pharmaceutically acceptable salt thereof have a prominent selective coronary vasodilator activity while having a minimized hypotensive effect. Therefore, they can selectively increase the coronary blood flow volume without the fear of causing sudden hypotension causative of tachycardia which adversely affects the heart, and hence are useful as a coronary vasodilator, in particular, as a preventive or remedy for cardiovascular disturbance such as angina pectoris or cardiac failure.

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Inventors:

CHO HIDETSURA
SAYAMA SHINSUKE
KATO SUSUMU
AISAKA KAZUO
UCHIDA ITSURO

Application Number:

JP51372096A

Publication Date:

September 03, 1997

Filing Date:

October 20, 1995

Export Citation:

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Assignee:

NIPPON TABAKO SANGYO KK

International Classes:

A61K31/35; A61K31/435; A61K31/44; A61K31/495; A61K31/50; A61K31/505; A61K31/535; C07D311/22; C07D311/68; C07D311/70; C07D405/04; C07D405/12; C07D487/04; C07D498/04; C08F255/00; C08F255/02; C08F255/04; C08F255/06; C08F255/08; C08F257/02; C08F279/02; C08L51/00; C08L51/06; C10M143/00; C10M149/06; C10M149/10; C10M151/02; C10M157/04; C10M167/00; C10N30/04; C10N40/25; (IPC1-7): C07D311/68; A61K31/35; A61K31/435; A61K31/44; A61K31/495; A61K31/50; A61K31/505; A61K31/535; C07D405/12; C07D487/04; C07D498/04

Domestic Patent References:

JP366681A
JP4300880A
JP5294954A
JP320275A

Other References:

【文献】国際公開94/4521(WO,A)

Attorney, Agent or Firm:

Takashima Hajime

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