Title:
【発明の名称】脂質とオリゴヌクレオチドの共有結合コンジュゲート
Document Type and Number:
Japanese Patent JPH04503957
Kind Code:
A
Abstract:
A conjugate is provided wherein a lipid is covalently coupled to an oligonucleotide having a nucleotide sequence that is either of interest or substantially complementary to a nucleotide sequence of interest. The conjugate is useful for nucleic acid purification, diagnostic methods, and therapeutic applications. The therapeutic aspect includes conjugates wherein the oligonucleotide contains an antisense nucleotide sequence to a sequence encoding a polypeptide responsible for a pathogenic disorder.
Inventors:
Bischoff Burger, Norbert W
Share, Regan Gee
Share, Regan Gee
Application Number:
JP50442190A
Publication Date:
July 16, 1992
Filing Date:
February 23, 1990
Export Citation:
Assignee:
Genentech, Inc.
International Classes:
A61K9/127; A61K31/70; A61K38/00; A61K47/48; A61K49/00; A61P31/12; C07H21/00; C07H21/04; C07J1/00; C07J51/00; C12N5/10; G01N33/53; C12N15/09; C12Q1/68; (IPC1-7): A61K9/127; A61K31/70; A61K37/22; A61K49/00; C07H21/04; C07J1/00; C12N5/10; C12N15/10; C12N15/87; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)