Title:
【発明の名称】ジアミノシクロブテン-3,4-ジオン
Document Type and Number:
Japanese Patent JPH10509145
Kind Code:
A
Abstract:
The compound of formula (I), wherein R1 and R2 are, independent from each other, hydrogen, C1-10 straight chain alkyl, C1-10 branched alkyl, or C3-10 cyclic or bicyclic alkyl; R3 is an acyl substituent selected from the group consisting of formyl, alkanoyl of 2 to 7 carbon atoms, alkenoyl of 3 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms, aroyl of 7 to 12 carbon atoms, arylalkenoyl of 9 to 20 carbon atoms, arylsulfonyl of 6 to 12 carbon atoms, arylalkanoyl of 8 to 12 carbon atoms or arylalkylsulfonyl of 7 to 12 carbon atoms; A is selected from the group consisting of (a), wherein R4 is hydrogen, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, amino, C1-6 alkylamino, C2-12 dialkylamino, C1-6 alkylsulfonamido, alkylcarboxamido containing 2 to 7 carbon atoms, nitro, cyano, carboxyl; or, A is a phenyl group of formula (b), wherein R5 and R6, independent from each other, are selected from the following: cyano, nitro, amino, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, C1-6 alkylamino, C2-12 dialkylamino, sulfamyl, C1-6 alkylsulfonamido, C6-12 arylsulfonamido, alkylcarboxamido containing 2 to 7 carbon atoms, arylcarboxamido containing 7 to 13 carbon atoms, C2 to C6 alkanoyl, C1-6 alkylsulfonyl, C1-6 perfluoroalkylsulfonyl, C6-12 arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl or hydrogen; or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants.
Inventors:
Madeleine Miyoko, Antein
Butera, John Anthony
Bradford Hammond, Hearth
Antein, Schiller Adam
Butera, John Anthony
Bradford Hammond, Hearth
Antein, Schiller Adam
Application Number:
JP51605395A
Publication Date:
September 08, 1998
Filing Date:
October 03, 1995
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
A61K31/165; A61K31/18; A61K31/275; A61P1/00; A61P13/02; A61P15/00; A61P21/00; C07C231/12; C07C233/41; A61K31/135; C07C255/60; C07C271/28; C07C311/05; C07C311/08; C07C311/18; C07D213/75; C07D217/02; (IPC1-7): C07C233/41; A61K31/135; A61K31/165; A61K31/18; A61K31/275; C07C231/12; C07C255/60; C07C311/05; C07C311/18
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)