Title:
NOVEL 5-PHENYL-2-BENZAZEPINE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5913761
Kind Code:
A
Abstract:
NEW MATERIAL:The 5-phenyl-2-benzazepine drivative of formula I (R is halogen, OH, nitro, or amino) and its salt.
EXAMPLE: 2-p-Chlrophenetyl-5-phenyl-2,3,4,5-tetrahydro-1H-2-benzazepine.
USE: Analgesic free from narcotic action, and having broad safety range and mild action.
PROCESS: The compound of formula I can be prepared by reacting 5-phenyl-2,3,4,5- tetrahydro-1H-2-benzazepine of formula II with the compound of formula III (X is halogen; R1 is halogen, acetoxy or nitro) in the presence of a reducing agent, and if necessary, reducing the nitro group of the resultant reaction product to amino group.
Inventors:
BAN MASATOSHI
MIURA KENJI
BABA YUTAKA
IWATA NORIYUKI
HORI MIKIO
FUJIMURA HAJIME
SUENAGA EIICHI
MIURA KENJI
BABA YUTAKA
IWATA NORIYUKI
HORI MIKIO
FUJIMURA HAJIME
SUENAGA EIICHI
Application Number:
JP12223282A
Publication Date:
January 24, 1984
Filing Date:
July 15, 1982
Export Citation:
Assignee:
SANWA KAGAKU KENKYUSHO CO
International Classes:
C07D223/16; A61K31/55; A61P3/00; A61P25/04; (IPC1-7): A61K31/55; C07D223/16
Domestic Patent References:
| JP46014658A | ||||
| JP43027873A |
Attorney, Agent or Firm:
Sasaki Isao