Title:
【発明の名称】薬剤組成物
Document Type and Number:
Japanese Patent JP2695852
Kind Code:
B2
Abstract:
Compounds of the formula Q-SO2-CH2-NO2 in which Q is an aromatic moiety of 6, 10 or 14 atoms, optionally bearing 1, 2 or 3 substituents which are independently selected from: hydrogen, halogeno, cyano, nitro, hydroxy, carboxy, amino, alkylamino or dialkylamino of up to 6 carbon atoms, (1-6C)alkanoylamino, (1-6C)alkanoyl, (1-6C)alkyl, (2-6C)alkenyl, (3-6C)alkenyloxy, fluoro(1-4C)alkyl, (1-6C)alkoxy, fluoro(1-4C)alkoxy, hydroxy(1-6C)alkyl, (1-4C)alkoxy(1-4C)alkyl, carbamoyl, alkyl or dialkylcarbamoyl of up to 7 carbon atoms, sulphamoyl, alkyl or dialkylsulphamoyl of up to 6 carbon atoms, (1-6C)alkoxycarbonyl, (1-4C)alkylenedioxy, (1-6C)alkanesulphonamido, (1-6C)alkyl.S(O)n- [in which n is zero, 1 or 2], phenyl, phenoxy, benzyloxy, benzyloxycarbonyl, benzamido and benzenesulphonamide, the benzene moiety of the last six groups optionally bearing a halogeno, (1-4C)alkyl or (1-4C)alkoxy substituent; or Q bears 4 or 5 substituents independently selected from halogeno, cyano, (1-6C)alkyl or (1-6C)alkoxy; but excluding the compounds in which Q is 2-carboxy-phenyl; are used in pharmaceutical compositions. These compounds may be prepared starting from: -an alkali metal sulfinate and nitromethane -a sulfone and an alkylnitrate -a thioether.
Inventors:
Stephen Paul Brown
Anthony Loren Cooper
Jethro Lawrence Longridge
Jeffrey James Morris
John Preston
Anthony Loren Cooper
Jethro Lawrence Longridge
Jeffrey James Morris
John Preston
Application Number:
JP19703088A
Publication Date:
January 14, 1998
Filing Date:
August 06, 1988
Export Citation:
Assignee:
Zeneca Limited
International Classes:
A61K31/10; A61K31/135; A61K31/165; A61K31/19; A61K31/275; A61K31/335; A61K31/357; A61K31/36; A61P3/08; A61P3/10; A61P43/00; C07C67/00; C07C313/00; C07C317/14; C07C317/22; C07C317/24; C07C317/32; C07C317/36; C07C317/44; C07C323/09; C12N9/99; C07C323/18; C07C323/22; C07C323/31; C07C323/62; C07D317/22; C07D317/60; C07D317/62; (IPC1-7): C07C317/44; A61K31/10; A61K31/135; A61K31/165; A61K31/19; A61K31/275; A61K31/335; A61K31/36; C07C317/14; C07C317/22; C07C317/24; C07C317/32; C07C323/09; C07C323/18; C07C323/22; C07C323/31; C07C323/62; C07D317/22
Other References:
JOURNAL OF POLYMER SCIENCE:POLYMER CHEMISTRY EDITION=1985
Attorney, Agent or Firm:
Kyozo Yuasa (3 outside)