Title:
【発明の名称】酵母および菌類における細胞死に関連する薬剤標的
Document Type and Number:
Japanese Patent JP2003504013
Kind Code:
A
Abstract:
The invention describes the use of the nucleic acid SEQ ID No 1 and polypeptide SEQ ID No 2 which are involved in a pathway eventually leading to programmed cell death of yeast or fungi for the preparation of a medicament for treating diseases associated with yeast or fungi or for the treatment of proliferative disorders or for preventing apoptosis in certain diseases. Methods are provided to identify compounds which selectively modulate the expression or functionality of said polypeptides in the same or a parallel pathway. Also provided are compounds as well as pharmaceutical compositions, medicaments and vaccines. The invention also comprises a new nucleic acid sequence, probes and primers derived thereof, expression vectors and host cells transformed with said vectors, polypeptides and antibodies raised against said polypeptides.
Inventors:
Contreras, Roland Henry
De Butzker, Marianne Dennis
Ruiten, Walter Hermann Maria Lewis
Renneltz, Isabelle Karin Peter
Narysen, Baltic-Joseph Maria
Leekmans, Rika Giosefuina
De Butzker, Marianne Dennis
Ruiten, Walter Hermann Maria Lewis
Renneltz, Isabelle Karin Peter
Narysen, Baltic-Joseph Maria
Leekmans, Rika Giosefuina
Application Number:
JP2001508323A
Publication Date:
February 04, 2003
Filing Date:
July 03, 2000
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/7088; A61K35/76; A61K36/06; A61K38/00; A61K39/00; A61K39/395; A61K45/00; A61K48/00; A61P9/10; A61P25/28; A61P31/10; A61P31/12; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07K14/37; C07K14/39; C07K14/395; C07K14/40; C07K14/47; C07K16/14; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/00; C12N15/09; C12N15/81; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; A01K67/027; C12R1/865; (IPC1-7): C12N15/09; A01K67/027; A61K31/7088; A61K35/70; A61K35/72; A61K35/76; A61K38/00; A61K39/00; A61K39/395; A61K45/00; A61K48/00; A61P9/10; A61P25/28; A61P31/10; A61P31/12; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07K14/395; C07K14/40; C07K14/47; C07K16/14; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Heiyoshi Odashima