Title:
【発明の名称】E.coliにおける機能的ヒトプラスミノーゲン活性化因子阻害剤(PAI―1)の高水準発現
Document Type and Number:
Japanese Patent JPH04505252
Kind Code:
A
Abstract:
Biologically functional mature E. coli-expressed recombinant PAI-1 is disclosed, as well as plasmid expression vectors for production of rPAI-1, and a method for identifying inhibitors of the binding of PAI-1 and t-PA.
Inventors:
Davis, Gary Lee
Nats, Robert Madara
Rayleigh, Thomas Michael
Sisc, William Perry
Nats, Robert Madara
Rayleigh, Thomas Michael
Sisc, William Perry
Application Number:
JP50756790A
Publication Date:
September 17, 1992
Filing Date:
May 08, 1990
Export Citation:
Assignee:
E.I.du Pont de Nemours & Company
International Classes:
A61K38/55; A61P7/04; C07K14/435; C07K14/705; C07K14/81; C12N1/21; C12N15/09; C12P21/02; G01N33/53; G01N33/573; G01N33/577; G01N33/86; A61K38/00; C12R1/19; (IPC1-7): A61K37/64; C07K15/06; C12N1/21; C12N15/15; C12P21/02; G01N33/53; G01N33/573; G01N33/577
Attorney, Agent or Firm:
Chika Takagi (2 outside)