Title:
4-CARBAMOYLOXYMETHYLCEPHEM DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5855491
Kind Code:
A
Abstract:
NEW MATERIAL:A compound shown by the formulaI(R1 is H or trichloroacetyl; R2 is H or methoxy; R3 is H or OH).
EXAMPLE: 7β-[D-2-( 6,7-Dihydroxychromone-3-carboxamido )-2-(4-hydroxyphenyl) acetamido]3-3 trichloroacetylcarbamoyloxymethyl-3-cephem-4-carboxylic acid.
USE: An antibacterial agent. Effective against Gram-negative bacteria such as Pseudomonas aeruginosa, Kleb. pneumoniae, etc.
PROCESS: A compound(salt) shown by the formula II is reacted with a compound (reactive derivative) shown by the formula III.
Inventors:
NEGI SHIGETO
MACHIDA YOSHIMASA
YAMAUCHI HIROSHI
SAITOU ISAO
HASEGAWA YOSHIKAZU
KAWAMURA TAMIO
MACHIDA YOSHIMASA
YAMAUCHI HIROSHI
SAITOU ISAO
HASEGAWA YOSHIKAZU
KAWAMURA TAMIO
Application Number:
JP15300981A
Publication Date:
April 01, 1983
Filing Date:
September 29, 1981
Export Citation:
Assignee:
EISAI CO LTD
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D501/34; C07D501/57; (IPC1-7): A61K31/545; C07D501/34; C07D501/57