Title:
【発明の名称】アリール-アミジンを持つXa因子阻害剤とその誘導体、及びそれらのプロドラッグ
Document Type and Number:
Japanese Patent JP2003523356
Kind Code:
A
Abstract:
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a pharmaceutically acceptable salt, a prodrug, a hydrate, a solvate or an isomer thereof, which are inhibitors of coagulation enzyme, factor Xa (FXa). The present invention also relates to a pharmaceutical composition containing the compound, and a method of using the same as an anticoagulant agent for treatment and prevention of thrombosis disorders.
Inventors:
Kang, Myung-Gyun
Park, Duhi
Kwon, Orfan
Kin, Wins Win-Kyung
Fan, Gwang-yeon
Fo, Yeon-Seki
Park, Tae-gyo
Lee, hee
Moon, Gwang-Yul
Park, Zhong-u
Chan, Hi-Kyung
Lee, Sung
Lee Sung-Hwa
Park Soo Kyung
Lee, Sun-Haku
Park, He Don
Park, Duhi
Kwon, Orfan
Kin, Wins Win-Kyung
Fan, Gwang-yeon
Fo, Yeon-Seki
Park, Tae-gyo
Lee, hee
Moon, Gwang-Yul
Park, Zhong-u
Chan, Hi-Kyung
Lee, Sung
Lee Sung-Hwa
Park Soo Kyung
Lee, Sun-Haku
Park, He Don
Application Number:
JP2001561005A
Publication Date:
August 05, 2003
Filing Date:
January 04, 2001
Export Citation:
Assignee:
Erg shii limited
International Classes:
A61K31/155; A61K31/167; A61K31/17; A61K31/18; A61K31/198; A61K31/216; A61K31/27; A61K31/277; A61K31/381; A61K31/40; A61K31/41; A61K31/417; A61K31/4178; A61K31/4196; A61K31/421; A61K31/426; A61K31/44; A61K31/4418; A61K31/4436; A61K31/4439; A61K31/4725; A61K31/5377; A61P7/02; A61P9/00; C07C257/18; C07C259/18; C07C271/20; C07C271/22; C07C271/64; C07C275/24; C07C275/40; C07C275/42; C07C311/06; C07C311/13; C07C311/16; C07C311/19; C07C311/29; C07C311/44; C07C311/46; C07C311/48; C07C317/40; C07C317/44; C07D207/27; C07D207/333; C07D207/34; C07D213/40; C07D213/04; C07D213/75; C07D213/78; C07D213/81; C07D213/82; C07D213/84; C07D217/22; C07D233/64; C07D233/84; C07D249/12; C07D263/22; C07D263/38; C07D265/10; C07D275/02; C07D277/20; C07D277/56; C07D333/34; C07D333/38; C07D401/10; C07D401/12; C07D403/10; C07D409/06; C07D409/12; C07D413/06; C07D417/06; C07D521/00; C07D207/26; C07D207/32; (IPC1-7): C07C257/18; A61K31/155; A61K31/167; A61K31/17; A61K31/18; A61K31/198; A61K31/216; A61K31/27; A61K31/277; A61K31/381; A61K31/40; A61K31/41; A61K31/417; A61K31/4178; A61K31/4196; A61K31/421; A61K31/426; A61K31/44; A61K31/4418; A61K31/4436; A61K31/4439; A61K31/4725; A61K31/5377; A61P7/02; A61P9/00; C07C271/20; C07C275/40; C07C311/13; C07C311/19; C07C311/29; C07C311/44; C07C317/40; C07D207/333; C07D207/34; C07D213/78; C07D213/81; C07D233/64; C07D249/12; C07D263/38; C07D275/02; C07D277/56; C07D333/38; C07D401/10; C07D403/10; C07D409/06; C07D409/12; C07D417/06
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)