Title:
【発明の名称】血友病の遺伝子療法
Document Type and Number:
Japanese Patent JPH09501306
Kind Code:
A
Abstract:
The invention provides a recombinant nucleic acid construct comprising: (i) a mammalian myosin heavy chain promoter; (ii) nucleic acid encoding a signal sequence; and (iii) nucleic acid encoding a functional blood clotting protein; the elements (i)-(iii) being operably linked to provide for expression of the functional protein. The construct is useful for the treatment of diseases such as haemophilia by introducing it into muscle cells. The activity of the promoter can be enhanced by exercise or stimulation of the muscle cells.
Inventors:
Golds pink, joffrey
Lee, Christine
Edward, Taddenham
Lee, Christine
Edward, Taddenham
Application Number:
JP50037594A
Publication Date:
February 10, 1997
Filing Date:
May 20, 1994
Export Citation:
Assignee:
Royal Free Hospital School of Medicine
International Classes:
C12N15/09; A61K31/70; A61K48/00; A61P7/02; C07K14/755; C12N1/21; C12N5/10; C12N15/85; C12P21/02; A61K38/00; C12R1/19; C12R1/91; (IPC1-7): C12N15/09; A61K31/70; A61K48/00; C12N1/21; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Akira Asamura (3 outside)