Title:
【発明の名称】多座配位性アミノポリカルボキシレート配位子との7族遷移金属錯体およびその調製用キット
Document Type and Number:
Japanese Patent JP2003503415
Kind Code:
A
Abstract:
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula (I): fac-[M(CO)3(OH2)3]<+>, wherein M is Mn, <99m>Tc, <186>Re or <188>Re, involves reacting a metal in permetallate form with carbon monoxide and a reducing agent, wherein a mixture of a basic borate buffer and a reducing agent soluble in water but not substantially decomposed by water is solved in a water containing solvent system containing a solution of the metal in permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide. The compound of formula (I) can be reacted with a ligand Lx to form a compound of formula (II): fac-[M(CO)3(X)2L1], wherein M is as defined above, Lx is a multidentate ligand, and n is a charge of the ligand Lx increased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.
Inventors:
Mary M. Disruski
Roger Albert
Joseph E. Bugaju
Roger Albert
Joseph E. Bugaju
Application Number:
JP2001507045A
Publication Date:
January 28, 2003
Filing Date:
June 28, 2000
Export Citation:
Assignee:
Mallinckrodt INC.
International Classes:
A61K51/04; C07C229/76; C07F13/00; A61K51/00; (IPC1-7): C07C229/76; A61K51/00
Domestic Patent References:
| JPH06510539A | 1994-11-24 |
Foreign References:
| WO1998048848A1 | 1998-11-05 |
Other References:
JPN5002010071, ＡＬＢＥＲＴＯ， ＲＯＧＥＲ, Ｊ． ＡＭ． ＣＨＥＭ． ＳＯＣ．, 1998, Ｖ１２０Ｎ３１, Ｐ７９８７−７９８８
JPN6010032685, ＪＯＮＧ，Ｍ．Ｄ． ｅｔ ａｌ．, "Ｃｏｍｐａｒｉｓｏｎ ｏｆ １１１Ｉｎ−ｌａｂｅｌｅｄ ｓｏｍａｔｏｓｔａｔｉｎ ａｎａｌｏｇｕｅｓ ｆｏｒ ｔｕｍｏｒ ｓｃｉｎｔｉｇｒａｐｈｙ ａｎｄ ｒａｄｉｏｎｕｃｌｉｄｅ ｔｈｅｒａｐｙ", Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ, 1998, Ｖｏｌ．５８， Ｎｏ．３, ｐ．４３７−４４１
JPN6010032686, ＨＯＳＯＮＯ，Ｍ． ｅｔ ａｌ．, "Ｌｏｃａｌｉｚａｔｉｏｎ ｏｆ ｓｍａｌｌ−ｃｅｌｌ ｌｕｎｇ ｃａｎｃｅｒ ｘｅｎｏｇｒａｆｔｓ ｗｉｔｈ ｉｏｄｉｎｅ−１２５−， ｉｎｄｉｕｍ−１１１−， ａｎｄ ｒｈｅｎｉｕｍ−１８８−ｓｏｍ", Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ, 1996, Ｖｏｌ．８７， Ｎｏ．９, ｐ．９９５−１０００
JPN6010032687, ＰＥＡＲＳＯＮ，Ｄ．Ａ． ｅｔ ａｌ．, "Ｓｏｍａｔｏｓｔａｔｉｎ Ｒｅｃｅｐｔｏｒ−Ｂｉｎｄｉｎｇ Ｐｅｐｔｉｄｅｓ Ｌａｂｅｌｅｄ ｗｉｔｈ Ｔｅｃｈｎｅｔｉｕｍ−９９ｍ ： Ｃｈｅｍｉｓｔｒｙ ａｎｄ Ｉｎｉｔｉａｌ Ｂｉｏｌｏｇｉｃａ", Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1996, Ｖｏｌ．３９， Ｎｏ．７, ｐ．１３６１−１３７１
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JPN6010032686, ＨＯＳＯＮＯ，Ｍ． ｅｔ ａｌ．, "Ｌｏｃａｌｉｚａｔｉｏｎ ｏｆ ｓｍａｌｌ−ｃｅｌｌ ｌｕｎｇ ｃａｎｃｅｒ ｘｅｎｏｇｒａｆｔｓ ｗｉｔｈ ｉｏｄｉｎｅ−１２５−， ｉｎｄｉｕｍ−１１１−， ａｎｄ ｒｈｅｎｉｕｍ−１８８−ｓｏｍ", Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ, 1996, Ｖｏｌ．８７， Ｎｏ．９, ｐ．９９５−１０００
JPN6010032687, ＰＥＡＲＳＯＮ，Ｄ．Ａ． ｅｔ ａｌ．, "Ｓｏｍａｔｏｓｔａｔｉｎ Ｒｅｃｅｐｔｏｒ−Ｂｉｎｄｉｎｇ Ｐｅｐｔｉｄｅｓ Ｌａｂｅｌｅｄ ｗｉｔｈ Ｔｅｃｈｎｅｔｉｕｍ−９９ｍ ： Ｃｈｅｍｉｓｔｒｙ ａｎｄ Ｉｎｉｔｉａｌ Ｂｉｏｌｏｇｉｃａ", Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1996, Ｖｏｌ．３９， Ｎｏ．７, ｐ．１３６１−１３７１
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)