Title:
【発明の名称】HA-1抗原
Document Type and Number:
Japanese Patent JP2001510851
Kind Code:
A
Abstract:
Peptide sequences constituting T-cell epitopes of minor Histocompatibility antigen, HA-1. HA-1 is associated with Graft versus Host Disease. The peptides and their derivatives find many uses, for instance, in bone marrow transplantation, organ transplantation and in treatment of leukemia and non-hematopoietic tumors. The peptide and/or its derivatives can be incorporated in vaccines, in pharmaceutical formulations and they can be used in diagnostic test kits. HA-1 is expressed by non-hematopoietic tumor cells. While absent in normal epithelial cells, tumor cells and tumor cell lines, particularly from epithelial origin, express HA-1 and are recognized by HA-1 cytotoxic T-cells. The invention provides means and methods for HA-1 specific immunotherapy for HA-1-positive patients with non-hematopoietic tumor cells.
Inventors:
Houlmei, Els Ah Yeah Em.
Hunt, Donald F.
Angel Hard, Victor H.
Hunt, Donald F.
Angel Hard, Victor H.
Application Number:
JP2000504165A
Publication Date:
August 07, 2001
Filing Date:
July 23, 1998
Export Citation:
Assignee:
Ryuk Unibeltate To Leiden
International Classes:
C12N5/10; A61K35/14; A61K38/00; A61K38/17; A61K39/00; A61P35/02; A61P37/06; C07K7/06; C07K14/705; C07K14/74; C07K16/28; C12N5/07; C12N5/0781; C12N5/0783; C12N5/09; C12Q1/68; (IPC1-7): C07K7/06; A61K38/00; A61K39/00; A61P35/02; A61P37/06; C07K14/705; C12N5/10; C12N5/06
Attorney, Agent or Firm:
Masashi Yoshioka