Title:
【発明の名称】メタロプロテアーゼ阻害剤としてのヒドロキサム酸およびカルボン酸
Document Type and Number:
Japanese Patent JPH11504320
Kind Code:
A
Abstract:
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrix metalloproteinases, such as stromelysin, and inhibit the production of tumor necrosis factor alpha, and for the treatment of arthritis and other related inflammatory diseases. These novel compounds are represented by Formula I below: Formula I
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Inventors:
The Ay Cobson, Irina Chipola
Karl Peter Dechitsuko
Robert J. Joseph, Cherney
Karl Peter Dechitsuko
Robert J. Joseph, Cherney
Application Number:
JP53192096A
Publication Date:
April 20, 1999
Filing Date:
April 17, 1996
Export Citation:
Assignee:
The DuPont Merck Pharmaceuticals Company
International Classes:
C07D233/56; A61K31/165; A61K31/17; A61K31/195; A61K31/198; A61K31/215; A61K31/38; A61K31/381; A61K31/40; A61K31/4015; A61K31/415; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/445; A61K31/4458; A61P1/02; A61P9/00; A61P27/02; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C237/22; C07C259/06; C07C259/08; C07D207/16; C07D207/40; C07D211/60; C07D213/40; C07D233/64; C07D263/48; C07D277/20; C07D277/30; C07D277/40; C07D307/24; C07D333/38; (IPC1-7): C07C259/06; A61K31/165; A61K31/17; A61K31/195; A61K31/215; A61K31/38; A61K31/40; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/445; C07C259/08; C07D207/40; C07D211/60; C07D213/40; C07D233/56; C07D233/64; C07D263/48; C07D277/30; C07D277/40; C07D333/38
Attorney, Agent or Firm:
Chika Takagi (2 outside)