Title:
【発明の名称】腫瘍組織成長の制御に関する改良
Document Type and Number:
Japanese Patent JPH03503761
Kind Code:
A
Abstract:
Compounds of the general formula: wherein R is H, an acyl group or a hydrocarbyl group containing up to 6 carbon atoms, have cytotoxic activity against several tumours. The 4-hydroxylamino compound can be obtained directly from the corresponding 2,4-dinitro compound by selective chemical reduction or by the action of a nitroreductase obtainable from Walker tumour cells. The 2,4-dinitro compound is substantially devoid of cytotoxic activity except in relation to Walker tumour cells and hence can act as a prodrug in regimes where a prodrug is localised in vivo in the regions of a tumour to be treated and is then activated to the cytotoxic 4-hydroxylamino compound under the influence of the enzyme.
Inventors:
Roberts, Jiyoung Jei
Knotx, Lithium Jay
Freed Ross, Frank
Knotx, Lithium Jay
Freed Ross, Frank
Application Number:
JP50376289A
Publication Date:
August 22, 1991
Filing Date:
February 22, 1989
Export Citation:
Assignee:
Roberts, Jiyoung Jei
Knotx, Lithium Jay
Freed Ross, Frank
Knotx, Lithium Jay
Freed Ross, Frank
International Classes:
A61K31/395; A61K31/396; A61K38/44; A61P35/00; C07D203/08; C07D203/14; C12N9/02; C12P17/10; (IPC1-7): A61K31/395; A61K37/50; C07D203/08; C12N9/02
Attorney, Agent or Firm:
Heiyoshi Odashima