【発明の名称】分枝ヒドラゾンのリンカー類

Title:

【発明の名称】分枝ヒドラゾンのリンカー類

Document Type and Number:

Japanese Patent JP2000503639

Kind Code:

A

Abstract:

Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.

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Inventors:

King, dalton
Firestone, Raymond
Trail, pamela

Application Number:

JP52384197A

Publication Date:

March 28, 2000

Filing Date:

December 17, 1996

Export Citation:

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Assignee:

Bristol-Myers Squibb Company

International Classes:

A61K31/00; A61K31/40; A61K31/401; A61K31/4015; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K39/395; A61K47/48; A61P31/00; A61P31/12; A61P35/00; A61P37/00; C07C281/02; C07D207/452; C07H15/252; C07D207/44; (IPC1-7): C07D207/452; A61P31/12; A61P31/00; A61P35/00; A61P37/00; A61K31/4015; A61K31/704; A61K47/48; C07H15/252

Attorney, Agent or Firm:

Takashi Ishida (4 others)

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