PRODUCTION OF 4-DEDIMETHYLAMINO-12A-DEOXYTETRACYCLINE

Title:

PRODUCTION OF 4-DEDIMETHYLAMINO-12A-DEOXYTETRACYCLINE

Document Type and Number:

Japanese Patent JPH069524

Kind Code:

A

Abstract:

PURPOSE: To produce 4-dedimethylamino-12a-deoxytetracycline of high purity, effective for improving rheumatic arthritis, periodontitis, etc., in a high yield by reducing a new 4-dedimethylaminotetracycline-12a-ester derivative in the presence of zinc in a solvent.

CONSTITUTION: The objective 4-dedimethylamino-12a-deoxytetracycline of formula II or III is produced by reducing a new 4-dedimethylaminotetracycline-12a- ester derivative (e.g. 4-dedimethylamino-12a-formyltetracycline) of formula I (R is H, an alkyl, an aryl or an aralkyl) in the presence of zinc in a solvent. The new ester derivative of formula I can be obtained, e.g. by esterifying 4- dedimethylaminotetracycline.

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Inventors:

KIKUYAMA SHIGEKI
KAWAI TSUTOMU
HAMAZAKI TAKASHI
TAKIGAWA TETSUO

Application Number:

JP18590492A

Publication Date:

January 18, 1994

Filing Date:

June 18, 1992

Export Citation:

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Assignee:

KURARAY CO

International Classes:

C07C231/12; C07C235/40; C07C235/82; (IPC1-7): C07C235/82; C07C231/12; C07C235/40

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