Title:
【発明の名称】ペネムの製法
Document Type and Number:
Japanese Patent JP2922220
Kind Code:
B2
Abstract:
Antibacterial penems of formula (I): wherein R represents a) alkanoyloxymethyl or 1-(alkanoyloxy)ethyl wherein the alkanoyl moiety is a C2-C10 alkanoyl or C4-C8 cycloalkanoyl group; b) benzoyloxymethyl or 1-(benzoyloxy)ethyl; c) alkoxycarbonyloxymethyl or 1- (alkoxycarbonyloxy)ethyl; d) 3-phthalidyl; e) 2-oxo-1,3-dioxolan-4-yl unsubstituted or substituted by a C1-C4 alkyl group in the 5 position; f) -CH2COOR' wherein R' is a C1-C4 alkyl or benzyl; or g) 2-oxotetrahydrofuran-5-yl unsubstituted or substituted by a C1-C4 alkyl group at the 4 position; R1 is tetrahydrofuranyl or an unsubstituted or substituted C1-C4 alkyl, methylphenyl or methylphenoxymethyl group, the substituents being chosen from the groups: (i) carbamoyloxy, C1-C18 alkoxy, carboxy or free or protected hydroxy, and (ii) unsubstituted or substituted and/or fused pyridinium, N-methylpyrrolidinium or piperidinium, the substituents being a said group (i) or a C1-C4 alkyl group unsubstituted or substituted by a sulfonyloxy or carboxy group; and R2 represents a hydrogen atom or a hydroxy protecting group; are prepared by reducing a compound of formula (II> wherein R, R1 and R2 are as defined above.
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Inventors:
MARIA ARUTAMURA
FURANKO FURANKARANCHI
MARUSERO MARUCHI
FURANKO FURANKARANCHI
MARUSERO MARUCHI
Application Number:
JP17173689A
Publication Date:
July 19, 1999
Filing Date:
July 03, 1989
Export Citation:
Assignee:
FUARUMASHIA E ATSUPUJON SPA
International Classes:
C07D499/04; C07D499/06; C07D499/897; C07D499/88; (IPC1-7): C07D499/04; C07D499/06
Domestic Patent References:
| JP5665892A | ||||
| JP61180766A | ||||
| JP63316784A | ||||
| JP5799589A |
Other References:
Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．（１９８５），１０７，ｐａｇｅｓ ６３９８−６３９９
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)