Title:
【発明の名称】官能化導電性ポリマーを用いる測定方法及び診断具
Document Type and Number:
Japanese Patent JPH0780998
Kind Code:
B2
Abstract:
Electrically conducting homo- and/or copolymers and/or tripolymers can be produced from novel monomers, such as a 3-substituted 2,5-di(2-thienyl)pyrrole. The polymers exhibit unexpectedly high stability and conductivities, and can be functionalized, such as with an enzyme, like glucose oxidase, or an ion-specific binding site, like a crown ether, or an antigen, without adversely affecting the conductivity of the polymer. The functionalized, conducting polymer can be used in a diagnostic device to determine the presence and concentration of a specific analyte in a liquid medium. For example, the presence and concentration of glucose is determined by measuring the conductivity change in the polymer caused by the vibrational excitation induced in the enzyme, glucose oxidase, from its reaction with the glucose and/or by measuring a secondary effect of the enzyme/substrate reaction, such as the change in the conductivity of the conducting polymer caused by the generation of hydrogen peroxide during the glucose-glucose oxidase reaction.
Inventors:
James P. Alvarella
The Okay Noel
Paul Au Bogerhat
Frederick E Word
The Okay Noel
Paul Au Bogerhat
Frederick E Word
Application Number:
JP27112288A
Publication Date:
August 30, 1995
Filing Date:
October 28, 1988
Export Citation:
Assignee:
Miles Incorporated
International Classes:
C12Q1/26; C07D333/40; C07D409/04; C07D409/14; C07D419/14; C07D421/04; C07D421/14; C07D521/00; C08G61/10; C08G61/12; C12Q1/00; C12Q1/54; G01N33/532; G01N33/543; H01B1/12; (IPC1-7): C08G61/12; C07D333/40; C07D409/14; C07D419/14; G01N33/543
Domestic Patent References:
| JP6144921A | ||||
| JP61215296A | ||||
| JP6397626A |
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)
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