Title:
【発明の名称】骨喪失を防止する方法
Document Type and Number:
Japanese Patent JPH11511739
Kind Code:
A
Abstract:
Inhibiting bone loss comprises admin. of benzoquinolin-3-one deriv. of formula (I) or its salt. In (I), R and R1 are H; or R+R1 is a bond; R2 is H or 1-3C alkyl; R3 is H, Me or Et; either R4 and X-R5 are absent and R3 is not Et; or (R6)m is absent; and R3 is not H, R4, X-R5 are opt. present at positions 7, 8 or 9; R4 is H, halo, Me or Et; X is 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, a bond, SO, SO2, COX(CH2)n, YCO(CH2)n, CO, Z(CH2)n or SO3; Y is S, O or NH; Z is O or S; n is 0-3; R5 is e.g. perhalophenyl; phenyl, naphthalenyl, pyridinyl, pyrazinyl etc., (all opt. substd. by 1-3 of halo CF3, 1-4C alkyl, OH, 1-3C alkoxy, NO2 etc.); morpholino(1-3C alkyl); phenyl-(1-3C) alkylpiperidinyl etc.; m is 1 or 2; R6 is e.g. H, halo, NO2, CN, CF3, 1-6C alkyl, 1-6C alkoxy, COOH, 1-6C alkoxycarbonyl, amino, mono- or di-(1-4C alkyl)amino, amido etc.
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Inventors:
Odya, James E
New Bower, Blake El
New Bower, Blake El
Application Number:
JP53424996A
Publication Date:
October 12, 1999
Filing Date:
May 09, 1996
Export Citation:
Assignee:
ELI LILLY AND COMPANY
International Classes:
A61K31/00; A61K31/47; A61K31/473; A61K31/495; A61K31/4965; A61K31/497; A61K31/498; A61K31/50; A61K31/501; A61K31/505; A61K31/506; A61K31/517; A61K31/529; A61P19/00; A61P19/10; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D221/06; C07D405/04; C07D409/04; C07D409/10; C07D413/04; C07D413/12; C07D417/04; C07D417/12; C07D487/04; C07D495/04; (IPC1-7): A61K31/47; A61K31/00; A61K31/495; A61K31/50; A61K31/505
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)