Title:
【発明の名称】17-ベータ-置換アンドロスタ-3,5-ジエン-3-カルボン酸の製法
Document Type and Number:
Japanese Patent JPH10507176
Kind Code:
A
Abstract:
The disclosed invention is a process for preparing 17-beta-substituted-androsta-3,5-dien-3-carboxylic acids from 3-halo-17-beta-substituted-androsta-3,5-dienes. The process may be performed in either of two ways: (1) the 3-halo compound is reacted with a phosphine, a metal catalyst, and a coupling reagent in a suitable organic solvent, followed by hydrolyzation of the intermediate to a 3-carboxylic acid; or (2) the 3-halo compound is reacted with a phosphine, a metal catalyst, a strong aqueous base, and a phase transfer catalyst to produce the 3-carboxylic acid.
Inventors:
Bane, Neil Howard
McGuire, Michael Anthony
You, Marvin Sunfan
McGuire, Michael Anthony
You, Marvin Sunfan
Application Number:
JP51264395A
Publication Date:
July 14, 1998
Filing Date:
October 04, 1995
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
A61K31/56; A61K31/575; A61P43/00; C07J3/00; C07J7/00; C07J9/00; C07J31/00; C07J41/00; C07J43/00; C07J75/00; (IPC1-7): C07J3/00; C07J7/00; C07J9/00; C07J31/00; C07J41/00; C07J43/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)