Title:
【発明の名称】L-タロピラノシド誘導体の製造方法
Document Type and Number:
Japanese Patent JP2540400
Kind Code:
B2
Abstract:
The present invention relates to a L-talopyranoside derivative of the formula (I): (I) wherein, A is hydrogen atom, a lower alkyl group having 1 to 5 carbon atoms, or a hydroxyl-protecting group; B1 and B2, the same or different from each other, are independently hydrogen atom or a hydroxyl-protecting group; R1 and R2 may form a alkylene group with a carbon atom of 5-position of the sugar skeleton, or one of them is hydrogen atom and the other is CH2X wherein, X is hydrogen, or a protected or un-protected hydroxyl group. Provided that, the following compounds are excepted: wherein, B1 and B2 are independently hydrogen atom or acetyl. L-talopyronoside derivatives of the present invention is a very useful intermediate for the synthesis of anthracycline antibiotics having an antitumor activity. The process according to the invention has an advantage of significant reduction in the production cost and therefore expected to be very useful for the preparation of anthracycline antibiotics in an industrial scale.
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Inventors:
GYOKU MITSUHIRO
KIN FUMINARI
TEI TOIN
KIN FUMINARI
TEI TOIN
Application Number:
JP31618191A
Publication Date:
October 02, 1996
Filing Date:
November 29, 1991
Export Citation:
Assignee:
TOA SEIYAKU KK
International Classes:
C07H7/02; A61K31/35; A61K31/351; A61P35/00; C07D309/10; C07H15/04; C07H15/252; (IPC1-7): C07H15/04
Domestic Patent References:
| JP62145096A |
Other References:
ＣＡＲＢＯＨＹＤＲ．ＲＥＳ．，１６９（１９８７）Ｐ．６９−８１
Attorney, Agent or Firm:
Eiji Saegusa (2 others)