【発明の名称】N-置換ヒドロキシシクロアルキルアミン誘導体の製造方法

Title:

【発明の名称】N-置換ヒドロキシシクロアルキルアミン誘導体の製造方法

Document Type and Number:

Japanese Patent JP2002524550

Kind Code:

A

Abstract:

A process for the preparation of N-substituted-hydroxycycloalkylamine derivatives, that are useful intermediates for the synthesis of various organic chemicals including pharmaceutical and agrochemical compounds, represented by formula (1), by reacting a 1,2-dihydroxalkyl alcohol, represented by the following formula (2), with a thionyl halide to produce an intermediate 1,2-cyclosulfinylalkyl halide represented by the following formula (3); and then cyclizing that intermediate with an amine compounds represented by the following formula (4).In the above structural formuli, * represents an asymmetric carbon atom; R1 is hydrogen or an amino-protecting group; m is an integer of 1-3; and X is halogen. The reactant compounds as well as the compounds made according to this invention have the following substitution pattern:n=1, R2=OH, R3=H and m=1; n=1, R2=H, R3=CH2OH and m=2;n=2, R2=OH, R3=H; and m=2; and n=2, R2=H, R3=CH2OH and m=3.

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Inventors:

Kim Seong Jin
Kim Keon Il
Yang Kyung Yule

Application Number:

JP2000570150A

Publication Date:

August 06, 2002

Filing Date:

September 15, 1999

Export Citation:

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Assignee:

Samsung Fine Chemicals Company Limited

International Classes:

C07D327/10; C07B61/00; C07D207/06; C07D207/12; C07D211/22; C07D211/42; (IPC1-7): C07D207/12; C07D211/22

Attorney, Agent or Firm:

Minoru Nakamura (9 outside)

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