【発明の名称】プロスタグランジン中間体の製法

Title:

【発明の名称】プロスタグランジン中間体の製法

Document Type and Number:

Japanese Patent JP2746800

Kind Code:

B2

Abstract:

PURPOSE:To suppress the production of trans-type DELTA<5>-PGs formed as a by- product and obtain the subject intermediate by reacting a specific lactol with a ylide in a specific ethereal or an aromatic solvent. CONSTITUTION:A lactol expressed by formula I or II [Y is CH2-CH2, CH=CH, CH2CH2CH2, etc., with the proviso that the double bond is the cis-form when Y has the double bond; R1 is (substituted)1-12C aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, etc., R2 is 1-4C alkyl; Z, together with C to which it is bonded, forms cyclic acetal; X is R5OC(R3)R4 (R3 and R4 are H or 1-4C alkyl; R5 is 1-4C alkyl, cyclohexyl or benzyl; R4 and R5 together may form a ring)] is made to react with a ylide expressed by formula III [Ph is phenyl; Q is (substituted)2-6C hydrocarbon] in an ethereal or an aromatic solvent having <=25 deg.C melting point and 0.3-3.0 dipole moment to afford the objective compound.

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Inventors:

UENO TAKASHI
ODA TOMIO

Application Number:

JP23347392A

Publication Date:

May 06, 1998

Filing Date:

September 01, 1992

Export Citation:

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Assignee:

AARU TETSUKU UENO KK

International Classes:

C07D307/935; C07C405/00; C07D311/94; C07D317/30; C07D493/04; (IPC1-7): C07D307/935; C07C405/00; C07D311/94; C07D317/30; C07D493/04

Other References:

【文献】CHEMICAL ABSTRACTS;VOL.110(NO.26),P661 抄録番号57399F (1989)
【文献】CHEMICAL ABSTRACTS;VOL.106(NO.26),P575 抄録番号18237Z (1987)

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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