Title:
【発明の名称】S(+)-イブプロフェン粒子の製造方法
Document Type and Number:
Japanese Patent JP2840132
Kind Code:
B2
Abstract:
PCT No. PCT/AT95/00014 Sec. 371 Date Jul. 12, 1996 Sec. 102(e) Date Jul. 12, 1996 PCT Filed Jan. 26, 1995 PCT Pub. No. WO95/20382 PCT Pub. Date Aug. 3, 1995A process for the production of S(+)-ibuprofen-particles having improved flow properties comprises the steps that coarse-crystalline S(+)-ibuprofen is molten and then in a molten condition is finely distributed in a non-solving medium, preferably in cold water, and is chilled therein. This chilling results in a fine-crystalline primary structure that agglomerates to a secondary structure. In this agglomerate form the product is obtained which is filtered out and is dried. Such particles are suitable for direct pressing of tablets, optionally, tableting auxiliary substances being added, also for the production of tablets having a retarded release of the active substance.
Inventors:
MERAA TORUSUTEN
HANTEITSUHI GERUHARUTO
HETSUSE ERUNSUTO
HANTEITSUHI GERUHARUTO
HETSUSE ERUNSUTO
Application Number:
JP51978395A
Publication Date:
December 24, 1998
Filing Date:
January 26, 1995
Export Citation:
Assignee:
GEBURO BUROSHETSUKU GMBH
International Classes:
A61K9/16; A61K31/135; A61K31/19; A61K47/32; A61K47/38; A61K9/14; (IPC1-7): A61K31/19; A61K9/14; A61K47/32; A61K47/38; C30B29/54
Domestic Patent References:
| JP59167536A | ||||
| JP2223537A | ||||
| JP50142724A | ||||
| JP4500925A | ||||
| JP6502651A |
Attorney, Agent or Firm:
Akihide Sugimura (1 outside)