Title:
【発明の名称】テトラヒドロ葉酸類の製造方法
Document Type and Number:
Japanese Patent JPH0826022
Kind Code:
B2
Abstract:
The invention relates to a new process for the preparation of 5,10-methenyl-(6R)-, 5-formyl-(6S)- and/or 5-methyl-(6S)- tetrahydrofolic acid and of their salts, characterised in that an acid addition salt or the internal salt of 5,10-methenyl-(6R,S)- tetrahydrofolic acid is subjected to separation of diastereomers by fractional crystallisation and, if desired, the 5,10-methenyl-(6R)- tetrahydrofolic acid obtained is converted into 5-formyl-(6S)- tetrahydrofolic acid by treating with a hydrolysing agent or into 5-methyl-(6S)-tetrahydrofolic acid by treating with a reducing agent and/or a free acid obtained is converted into one of its salts by treating with a base.
Inventors:
Hans Rudolf Mueller
Martin Ullman
Joseph Conti
Guntel Mürdell
Martin Ullman
Joseph Conti
Guntel Mürdell
Application Number:
JP16548789A
Publication Date:
March 13, 1996
Filing Date:
June 29, 1989
Export Citation:
Assignee:
Eproba Actien Gezershyaft
International Classes:
A61K31/505; A61K31/519; A61P3/02; C07D475/04; C07D475/00; C07D487/14; (IPC1-7): C07D475/00; C07D475/04; C07D487/14
Domestic Patent References:
| JPS63115880A |
Foreign References:
| CH649550A5 |
Attorney, Agent or Firm:
Mitsuyoshi Ezaki (1 person outside)