Title:
【発明の名称】ウルソデオキシコール酸の製造方法
Document Type and Number:
Japanese Patent JP2744062
Kind Code:
B2
Abstract:
PURPOSE:To obtain the title compound useful as a cholagogue in high purity and high yield by subjecting 3-hydroxy-7-ketocholanic acid or 3-hydroxy-7- keto-11-choleic acid in the presence of a base using a palladium based catalyst. CONSTITUTION:3-Hydroxy-7-ketocholanic acid or 3-hydroxy-7-keto-11-choleic acid which is a raw material is subjected to catalytic hydrogenation, preferably in the presence of a base (used at an amount of 0.5-3 equivalent based on 1 equivalent of the above-mentioned raw material) such as alkali metal alcoholate, preferably using a palladium-carbon catalyst (used at an amount of 0.01-50weight% as metal content based on the above-mentioned raw material) in a solvent (used at same amount as the above-mentioned raw material to amount corresponding to 100 times the above-mentioned raw material) such as water, ethanol or hexane in 1-300kg/cm<2> pressure at 20-200 deg.C to provide the aimed compound.
Inventors:
Naohiro Kubota
Shinya Mashita
Shinya Mashita
Application Number:
JP10397989A
Publication Date:
April 28, 1998
Filing Date:
April 24, 1989
Export Citation:
Assignee:
Asahi Denka Kogyo Co., Ltd.
International Classes:
C07J9/00; B01J23/44; C07B61/00; C07J75/00; (IPC1-7): C07J9/00; C07J75/00
Attorney, Agent or Firm:
Osamu Hatori