Title:
【発明の名称】フリル銅試薬を用いるプロスタグランジンE1、E2およびこれらの類似体の調製法
Document Type and Number:
Japanese Patent JP2840457
Kind Code:
B2
Abstract:
A process for synthesizing prostaglandin E1, E2 and derivatives thereof is provided. The process is a "one-pot" method in which 2-furyllithium, copper cyanide, a lower alkyllithium reagent and either an (E)-alkenylstannane or a halogenide are combined with cyclopentenone (II) (II) in which A, R6 and R7 are as defined herein. The reaction gives rise to the desired prostaglandin product in yields of 80% or higher.
Inventors:
TORANHOOTA MIROSUROFU
ZAKU BOFUMIRU
ZAKU BOFUMIRU
Application Number:
JP52770796A
Publication Date:
December 24, 1998
Filing Date:
March 07, 1996
Export Citation:
Assignee:
BIBASU INC
International Classes:
C07C405/00; (IPC1-7): C07C405/00
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)