【発明の名称】光学活性アミン類の製造方法

Japanese Patent JP2912572

B2

PROBLEM TO BE SOLVED: To obtain the subject compound useful as a synthetic intermediate for a medicine, a reagent for optical resolution, by using a catalyst high in generality, activity and selectivity and subjecting an imine compound to a hydrogen transfer type asymmetric reduction. SOLUTION: This optically active amine is produced by subjecting an imine compound to a hydrogen transfer type asymmetric reduction in the presence of a transition metal complex, an optically active nitrogen-containing compound and a hydrogen donative organic or inorganic compound. A compound of formula I (R<1> is an aromatic monocyclic or polycyclic hydrocarbon, an alicyclic hydrocarbon, a cyclic hydrocarbon, etc.; R<2> and R<3> are each H, an aromatic hydrocarbon, etc.) is especially preferable as the imine compound. A compound of formula II is preferable as the optically active amine. A metal complex of a metal of the group VIII (e.g. a compound of formula III) is preferable as the transition metal complex. An optically active amine derivative is preferable as the optically active nitrogen-containing compound. An alcohol compound, formic acid, a formate, a hydrocarbon compound, a heterocyclic compound, hydroquinone or phosphorous acid is preferable as the hydrogen donative organic or inorganic compound.

IKARYA TAKAO
UEMATSU NOBUYUKI
HASHIGUCHI SHOHEI
FUJII AKIO
NOYORI RYOJI

JP31830495A

June 28, 1999

December 06, 1995

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KAGAKU GIJUTSU SHINKO JIGYODAN
NIPPON KOKAN KK
ASAHI KASEI KOGYO KK
TAKEDA YAKUHIN KOGYO KK

C07D217/02; B01J31/16; C07B61/00; C07C209/52; C07C211/27; C07C211/42; C07C211/44; C07D209/08; C07D211/86; C07D495/04; (IPC1-7): C07C211/27; B01J31/16; C07C209/52; C07C211/42; C07C211/44; C07D209/08; C07D211/86; C07D217/02; C07D495/04

Toshio Nishizawa

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