Title:
【発明の名称】ラニチジンの製法
Document Type and Number:
Japanese Patent JPH06102656
Kind Code:
B2
Abstract:
Compounds of formula (II> in which R1 is C1-4 alkyl, preferably methyl, are prepared by reaction of a compound of formula (I> where Q is hydrogen or a cation derived from a suitable base with a suitable alkylating agent such as an alkyl halide or a dialkyl sulphate. The compound of formula (II) may be converted into a histamine H2-antagonist containing an -NHC(=CHNO2)NHCH3 end group, e.g. ranitidine, by reaction with an appropriate amine. The compound of formula (I) (compounds where Q is H or alkali metal are said to be novel) may be prepared by reaction of methyl isothiocyanate with the carbanion of nitromethane (preferably generated in situ by reaction of nitromethane with a suitable base) in the presence of dimethyl sulphoxide as solvent, Q representing the cation derived from the base used to produce the carbanion of nitromethane.
Inventors:
John, Frederick, Seger
Roger, Dancy
Roger, Dancy
Application Number:
JP23058993A
Publication Date:
December 14, 1994
Filing Date:
September 16, 1993
Export Citation:
Assignee:
GLAXO GROUP LTD.
International Classes:
B01J31/00; B01J31/02; C07C67/00; C07C319/02; C07C313/00; C07C319/14; C07C323/27; C07C331/00; C07D307/38; C07D307/52; (IPC1-7): C07D307/52
Attorney, Agent or Firm:
Kazuo Sato (2 outside)