Title:
【発明の名称】トロンビンの製造方法
Document Type and Number:
Japanese Patent JP3404038
Kind Code:
B2
Abstract:
Methods are disclosed for producing thrombin. The protein is produced from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. The DNA constructs generally include the following operably linked elements: a transcriptional promoter, DNA sequence encoding a gla-domainless prothrombin, and a transcriptional terminator. Thrombin precursors produced from transformed or transfected host cells are activated either in vivo or in vitro.
Inventors:
Holly, Richard Dee.
Foster, Donald Sea.
Foster, Donald Sea.
Application Number:
JP51196893A
Publication Date:
May 06, 2003
Filing Date:
December 30, 1992
Export Citation:
Assignee:
Zymogenetics, Incorporated
International Classes:
A61K38/46; A61P7/04; C07K14/39; C12N1/19; C12N5/10; C12N9/72; C12N9/74; C12N15/00; C12N15/09; C12N15/57; G02F1/167; G09F9/37; A61K38/00; C12R1/865; C12R1/91; (IPC1-7): C12N15/09; A61K38/46; A61P7/04; C12N1/19; C12N5/10; C12N9/74
Other References:
【文献】国際公開91/011519(WO,A1)
Attorney, Agent or Firm:
Takashi Ishida (2 outside)