Title:
【発明の名称】セファレキシンの回収方法
Document Type and Number:
Japanese Patent JPH11503408
Kind Code:
A
Abstract:
The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any solid cephalexin being present is homogeneous at a pH between 7 and 8.5, is subjected to a pH modification until a pH lower than 7.8 is reached, and the solid substance is recovered. The disclosed process is particularly suited for application to a reaction mixture obtained after the enzymatic acylation reaction of 7-ADCA with a phenylglycine derivative as an acylation agent. Pure cephalexin can thus be recovered in a simple manner.
Inventors:
Boesten, Wilhelms, Hvartas, Joseph
Ruth, Eric, Cornelis
Van den Tyr, Wilhelms, Johannes, Joseph
Ruth, Eric, Cornelis
Van den Tyr, Wilhelms, Johannes, Joseph
Application Number:
JP52343696A
Publication Date:
March 26, 1999
Filing Date:
February 01, 1996
Export Citation:
Assignee:
Chem Farm Buoy.
International Classes:
C07D501/00; C07D501/12; C07D501/22; C12P35/00; C12P35/04; (IPC1-7): C07D501/12; C07D501/22; C12P35/00; C12P35/04
Attorney, Agent or Firm:
Mitsuo Matsui
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