【発明の名称】N―[4―(ヘテロアリールメチル)フェニル]―ヘテロアリールアミン - JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP

Title:

【発明の名称】N―[4―(ヘテロアリールメチル)フェニル]―ヘテロアリールアミン

Document Type and Number:

Japanese Patent JP3404749

Kind Code:

B2

Abstract:

The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R¹is hydrogen, hydroxy, C_1-6alkyl or aryl; R²is hydrogen; optionally substituted C_1-12alkyl; C_3-7cycloalkyl; C_2-8alkenyl, optionally substituted pyrrolidinyl or aryl; R³is hydrogen, optionally substituted C_1-6alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.

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Inventors:

Marc Gaston, Benet
Maville, Dominique Jean-Pierre
Lachlan, Jijan Fernand Armand
Saint-Jérard-Cialur

Application Number:

JP50232198A

Publication Date:

May 12, 2003

Filing Date:

June 19, 1997

Export Citation:

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Assignee:

JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP

International Classes:

A61K31/00; A61K31/41; A61K31/415; A61K31/4164; A61K31/4184; A61K31/42; A61K31/423; A61K31/425; A61K31/427; A61K31/435; A61K31/4353; A61K31/437; A61K31/44; A61K31/4427; A61K31/4439; A61K31/445; A61K31/4465; A61K31/4523; A61K31/454; A61K31/47; A61K31/472; A61K31/4725; A61K31/495; A61K31/496; A61K31/4965; C07D473/34; A61K31/497; A61K31/498; A61K31/50; A61K31/501; A61K31/502; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/52; A61K31/529; A61K31/535; A61K31/5375; A61K31/5377; A61P17/00; A61P17/06; A61P35/00; A61P43/00; C07D277/22; C07D401/12; C07D403/12; C07D413/12; C07D417/12; C07D513/04; C07D521/00; (IPC1-7): C07D417/12; A61K31/4184; A61K31/423; A61K31/427; A61K31/437; A61K31/4439; A61K31/454; A61K31/4725; A61K31/496; A61K31/497; A61K31/498; A61K31/501; A61K31/502; A61K31/506; A61K31/517; A61K31/519; A61K31/52; A61K31/5377; A61P35/00; A61P43/00; C07D401/12; C07D403/12; C07D413/12; C07D473/34; C07D513/04

Other References:

【文献】国際公開96/015118(WO,A1)

Attorney, Agent or Firm:

Heiyoshi Odashima (1 person outside)

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