Title:
【発明の名称】N▲上6▼-(ヒドラジノイミノメチル)リジン及び生体における一酸化窒素形成の阻止法
Document Type and Number:
Japanese Patent JP3199265
Kind Code:
B2
Abstract:
Physiologically active N6-(hydrazinoiminomethyl)lysine or pharmaceutically acceptable acid addition salt thereof is administered in a nitric oxide sythesis inhibiting amount to a subject in need of such inhibition (e.g., a subject with low blood pressure, e.g., due to sepsis or to therapeutic administration of cytokines, or needing immunosuppressive effect) or is added to a medium containing isolated organs, intact cells, cell homogenates or tissue homogenates in an amount sufficient to inhibit nitric oxide formation to elucide or control the biosynthesis, metabolism or physiological role of nitric oxide. Compared to known nitric oxide synthesis inhibitors, N6-(hydrazinoiminomethyl)lysine and its acid addition salts show a greater relative activity toward inducible isoform of nitric oxide synthase than toward constitutive isoform of nitric oxide synthase. N6-(hydrazinoiminomethyl)lysine and its pharmaceutically acceptable acid addition salts are substantially less toxic than are NG-amionoarginine and its pharmaceutically acceptable acid addition salts.
Inventors:
Griffith, Owen W
Application Number:
JP50906292A
Publication Date:
August 13, 2001
Filing Date:
March 13, 1992
Export Citation:
Assignee:
Cornell Research Foundation, Inc.
International Classes:
A61P31/04; A61P37/06; A61P43/00; C07C281/16; A61K31/195; (IPC1-7): C07C281/16; A61K31/195; A61P37/06; A61P43/00
Domestic Patent References:
| JP4270255A |
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)