【発明の名称】N-[(脂肪族又は芳香族)カルボニル]-2-アミノアセトアミド化合物及び環化化合物の製造方法

Japanese Patent JP2002501944

A

The present invention relates to a method for preparing an N-[(aliphatic or aromatic)carbonyl]-2-aminoacetamide compound of formula (I) wherein Ra is (II); Raa is hydrogen, optionally substituted aliphatic or optionally substituted aromatic; Rb is hydrogen, optionally substituted aliphatic or optionally substituted aromatic; Rca and Rcb are independently hydrogen, optionally substituted aliphatic or optionally substituted aromatic; Rd is (III); and Rda is optionally substituted aliphatic or optionally substituted aromatic; and Raa is substituted with a primary or secondary protected amine that upon deprotection can react with the *ab or *db carbon, or at least one of Rb, Rca or Rcb where each is at least substituted with an activated carboxylic acid to form a 5-7 membered cyclic ring; or Rb is substituted with a primary or secondary protected amine that upon deprotection can react with the *ab or *db carbon, or at least one of Raa, Rca or Rcb where each is at least substituted with an activated carboxylic acid to form a 5-7 membered cyclic ring; or Rca and Rcb are independently substituted with a primary or secondary protected amine that upon deprotection can react with the *ab or *db carbon, or at least one of Raa, Rb, Rca, Rcb or Rda where each is at least substituted with an activated carboxylic acid to form a 5-7 membered cyclic ring; or Rda is substituted with a primary or secondary protected amine that upon deprotection can react with at least one of Rca or Rcb where each is at least substituted with an activated carboxylic acid to form a 5-7 membered cyclic ring, provided that when Raa is substituted with a primary or secondary protected amine that upon deprotection can react with Rb at least substituted with an activated carboxylic acid, then Raa is other than substituted aliphatic, comprising reacting the following four compounds: a carbonyl compound of formula (IV), an amine compound of formula NH2Rb, an isonitrile compound of formula NCRda, and an acid compound of formula RaCO2H, to produce the N-[(aliphatic or aromatic)carbonyl]-2-aminoacetamide compound, and the N-[(aliphatic or aromatic)carbonyl]-2-aminoacetamide compound. The invention is also directed to a method for cyclizing N-[(aliphatic or aromatic)carbonyl]-2-aminoacetamide compound to a cyclic compound selected from the group consisting of a 1,4-benzodiazepine-2,5-dione derivative, diketopiperazine derivative, ketopiperazine derivative, lactam derivative, 1,4-benzodiazapine derivative and dihydroquinoxalinones derivative, and the cyclized compound.

JP4063320	Novel asymmetric synthesis of R and S warfarin and similar compounds
JP2009533431	Mixed alcohol synthesis with improved carbon value use

Harum Christopher
Morton George Sea
Salvino joseph em
La Bodiniere Richard F
Mason Helen Jay
Morese Matthew M
Marie Ann
Chelier Marie Pierre

JP2000530081A

January 22, 2002

January 29, 1999

Click for automatic bibliography generation  

Aventis Pharmaceuticals Products, Inc.

C07B61/00; C07C231/14; C07C269/04; C07C269/06; C07C271/22; C07D207/14; C07D207/273; C07D233/28; C07D233/54; C07D233/64; C07D233/90; C07D241/08; C07D241/18; C07D241/36; C07D241/44; C07D243/14; C07D243/24; C07D295/12; C07D401/04; C07D401/12; C07D403/04; C07D403/06; C07D403/12; C07D405/06; C07D405/12; C07D409/06; C07D521/00; C07F9/645; C07C237/22; C07C271/28; C07D207/26; (IPC1-7): C07C269/04; C07B61/00; C07C271/22; C07D207/14; C07D233/64; C07D233/90; C07D241/08; C07D241/36; C07D243/14; C07D295/12; C07D401/04; C07D401/12; C07D403/04; C07D403/06; C07D403/12; C07D405/06; C07D405/12; C07D409/06

JPN6010013289, Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ, 1996, Ｖｏｌ．　６１，　Ｎｏ．　２５, ８９３５−８９３９, US
JPN6010013290, Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ, 1996, Ｖｏｌ．　１１８，　Ｎｏ．　１１, ２５７４−２５８３, US

Minoru Nakamura (9 outside)

Previous Patent: JP2002501943

Next Patent: ＰＰＡＲ−ガンマ調節剤