Title:
【発明の名称】N―(メルカプトアルキル)尿素およびカルバミン酸塩
Document Type and Number:
Japanese Patent JPH06500326
Kind Code:
A
Abstract:
PCT No. PCT/US91/05587 Sec. 371 Date Feb. 11, 1993 Sec. 102(e) Date Feb. 11, 1993 PCT Filed Aug. 14, 1991 PCT Pub. No. WO92/03410 PCT Pub. Date Mar. 5, 1992.Novel N-(mercaptoalkyl)urea or carbamates of the formulae I and II I II wherein A is a monocyclic or bicyclic arylene or heteroarylene; Q is hydrogen or R9CO-; Y is -O-,-S- or -NR8-; R1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl; R2 and R8 are independently hydrogen; lower alkyl; cyclolower alkyl; substituted lower alkyl; aryl; or heteroaryl; R3 is -OR5 or -NR5R6; R4 is -(CH2)qR7; or R2 and R4 and the carbons to which they are attached complete a ring; R5 and R6 are hydrogen, lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl or aryl lower alkyl, or R5 and R6 together with the nitrogen to which they are attached form a ring; and the pharmaceutically acceptable salts thereof useful in the treatment of cardiovascular disorders, nephrotoxicity and pain conditions and combinations of N-(mercaptoalkyl)ureas or carbamates and atrial natriuretic factors or angiotensin convening enzyme inhibitors useful for treating cardiovascular disorders are disclosed.
Inventors:
Newstat, Bernard Earl
Bronenkanto, Alan
Bronenkanto, Alan
Application Number:
JP51450691A
Publication Date:
January 13, 1994
Filing Date:
August 14, 1991
Export Citation:
Assignee:
SCHERING CORPORATION
International Classes:
A61K31/19; A61K31/195; A61K31/215; A61K31/235; A61K31/245; A61K31/40; A61K31/495; A61P9/00; A61P9/12; A61P13/02; A61P15/00; A61P21/00; A61K31/16; A61P25/04; A61P25/18; C07C323/43; C07C323/44; C07C327/30; C07C333/04; (IPC1-7): C07C323/43; A61K31/16; A61K31/19; A61K31/195; A61K31/215; A61K31/235; A61K31/245; A61K31/40; A61K31/495; C07C323/44; C07C327/30
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)