Title:
【発明の名称】新規化合物
Document Type and Number:
Japanese Patent JPH05507071
Kind Code:
A
Abstract:
Isoquinoline derivatives (I) having 5-HT3 receptor antagonist activity, a process for their preparation and their use as pharmaceuticals. In formula (I) E is NH or O, R1 is hydrogen, halogen, alkyl, alkoxy, hydroxy or nitro; Z is an azacyclic or azabicyclic side chain, such as a group of formula (a), (b) or (c) wherein; p is 1 or 2; q is 1 to 3; r is 1 to 3; R3 or R4 is hydrogen or alkyl, and Y is a group -CH2-X-CH2- wherein X is -CH2-, oxygen, sulphur or X is a bond; and (I) when the group CO-E-Z is in the 1-position and either R2 is in the 3-position and is hydrogen, alkyl, or alkoxy, or R2 is in the 4-position and is hydrogen CF3, alkyl, acyl, acylamino (substituted) phenyl or (substituted) amino, (substituted) aminocarbonyl or (substituted) aminosulphonyl; (II) the group CO-E-Z- is in the 3-position and either R2 is in the 1-position and is hydrogen, alkyl or alkoxy or R2 is in the 4-position and is hydrogen or alkoxy.
Inventors:
King, francis david
Application Number:
JP50821191A
Publication Date:
October 14, 1993
Filing Date:
April 22, 1991
Export Citation:
Assignee:
Beechham Group PLC
International Classes:
A61K31/47; A61K31/55; A61P1/00; A61P1/08; A61P25/00; A61P25/04; A61P43/00; C07D451/04; C07D451/12; C07D451/14; C07D453/02; C07D453/06; C07D471/08; C07D498/08; C07D513/08; (IPC1-7): C07D451/04; A61K31/47; A61K31/55; C07D451/12; C07D451/14; C07D453/02; C07D453/06; C07D471/08; C07D498/08; C07D513/08
Attorney, Agent or Firm:
Masamitsu Akizawa (1 person outside)