Title:
【発明の名称】新規甲状腺レセプターリガンドおよび方法
Document Type and Number:
Japanese Patent JP2002513422
Kind Code:
A
Abstract:
Novel thyroid receptor ligands are provided which have the general formula (I)where R1 is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 3 carbons or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being other than hydrogen; n is an integer from 0 to 4; R4 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid ester thereof, alkenyl carboxylic acid or ester thereof, hydroxy, halogen, cyano, or a phosphonic acid or an ester thereof, or a pharmaceutically acceptible salt thereof. A method for treating diseases associated with metabolism dysfunction or which are dependent on the expression of a T3 regulated gene, such as obesity, hypercholesterolemia, osteoporosis, hypothyroidism, and goiter, is also provided.
Inventors:
Lee, Lee Lin
Ryu, Ye
Head Force, Arthur
Marum, Joan
Merlin, Charlotte
Tsang, Minsheng
Ryu, Ye
Head Force, Arthur
Marum, Joan
Merlin, Charlotte
Tsang, Minsheng
Application Number:
JP50530199A
Publication Date:
May 08, 2002
Filing Date:
June 26, 1998
Export Citation:
Assignee:
Caro Bio Actebrague
International Classes:
A61K31/085; A61K31/192; A61K31/275; A61P3/00; A61P3/04; A61P3/06; A61P5/14; A61P9/02; A61P9/06; A61P9/10; A61P19/10; A61P25/24; A61P27/06; A61P35/00; C07C41/18; C07C43/295; C07C59/68; C07C65/24; C07C255/37; C07F9/38; C07F9/40; A61K31/662; (IPC1-7): C07C43/295; A61K31/085; A61K31/192; A61K31/275; A61K31/662; A61P3/00; A61P3/04; A61P3/06; A61P5/14; A61P9/02; A61P9/06; A61P9/10; A61P19/10; A61P25/24; A61P27/06; A61P35/00; C07C41/18; C07C59/68; C07C65/24; C07C255/37; C07F9/40
Attorney, Agent or Firm:
Tsutomu Toyama (4 others)